THE EFFECT OF INTRAVENOUS STEM CELLS INJECTION ON THE INDICATORS OF THE ANTIOXIDANT SYSTEM OF KIDNEYS OF RATS AFTER APPLICATION OF A BONE DEFECT

Introduction. Dysfunction of the kidneys after a bone fracture significantly increases recovery time patients, risk complications and disability. Recently, mesenchymal stem cells have been used to restore both kidney tissue. Our study was devoted effect on processes lipid peroxidation (LPO) work antioxidant system injury.Materials methods. The carried out 120 male white rats weighing from 190 225 grams, which were divided into 3 groups: K – control animals, D animals that inflicted with defect in tibia (TBC), DM received corrections injected intravenously allogeneic cells. 7th, 15th, 30th, 60th 90th days operation. activity determined by level malondialdehyde (MDA), non-enzymatic link defense reduced glutathione (GSH). Results. After application defect, there significant increase MDA, as well decrease glutathione. More pronounced changes observed 7th day intravenous injection cells, faster (from 7) studied parameters took place. Conclusion. use cell therapy LBC leads more rapid restoration peroxidation.